Fig. 6. Recordings of effects of the soluble guanylate cyclase inhibitor ODQ
(1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one) and of cGMP-specific
phosphodiesterase inhibitor zaprinast on peristaltic contractions of reduced
preparations. Note the enhancing effect of ODQ in contrast to the additive
depressing effects of zaprinast and db cGMP. The latter two also depressed
basal tension below initial level (dotted line).