Fig. 2. Phylogenetic analysis of fish Wap65s and mammalian hemopexins. The neighbor-joining method with Poisson distance matrix was used to infer the tree topology. Bootstrap values (%) are shown at each branch point of the tree. The scale at the bottom is in units of amino acid substitutions per site. Data are cited for goldfish Wap65 (Kikuchi et al., 1995), carp Wap65 (Kinoshita et al., 2001) and rainbow trout hemopexin-like protein (Miot et al., 1996), and hemopexins of rabbit (Morgan et al,. 1993), rat (Nikkilä et al., 1991) and human (Altruda et al., 1985; Takahashi et al., 1985).