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Fig. 1. The reactions catalyzed by phosphofructokinase (PFK) and fructose-1,6-bisphosphatase (FbPase). PFK phosphorylates fructose-6-phosphate (F6P), hydrolyzing ATP in the process. FbPase catalyses the hydrolysis of fructose-1,6-bisphosphate (F1,6bP) to F6P, releasing inorganic phosphate (Pi).