Fig. 1. Depicts the major CRH-ir cells groups and CRH-ir pathways in a sagittal section of the brain of tilapia (original data in Pepels et al., 2002a, 2004). Each circle represents approximately 25 CRH-ir cells. The hypophysiotropic CRH-ir neurons located in the nucleus preopticus (npo), nucleus recessus lateralis (nrl) and nucleus lateralis tuberis (nlt) project into the pituitary (pit). The largest CRH-ir cell group is found in the lateral part of the ventral telencephalon (Vl) and projects mainly into the anterior subdivision of the lateral part of the dorsal telencephalon (Dla). CRH-ir terminals have also been found locally in Vl. Many blood capillaries are found in close proximity of the CRH-ir cells in Vl and a collecting vein is located in the sulcus of Vl (Pepels et al., 2004). In the vagal lobe (LX) CRH-ir terminals are present.