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Fig. 4. Frequency distribution of sharks displaying commenced blood flow in the longitudinal vessels during (A) hypoxia (grey bars; N=12) and (B) adenosine injection (1 µmol kg–1) (grey bars; N=8), and after aminophylline treatment during (A) hypoxia (hatched bars; N=6) and (B) adenosine injections (1 µmol kg–1) (hatched bars; N=7). Injection of adenosine at time 0. An asterisk indicates a significant difference between aminophylline treated and control group (*P<0.05, **P<0.01) (Fisher's exact test).