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Fig. 5. (A) Plasma cortisol is shown to increase at calcium-limiting conditions. (B) Parathyroid hormone related protein (PTHrP) increases when calcium is limited in the diet or the medium. However, when both external calcium sources are limited, PTHrP shows no rise in plasma level. Asterisks represent significant difference (P<0.05) compared with the control group. Values are means ± S.D.