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Fig. 4. Effects of L-N5-N-iminoethyl-L-ornithine (L-NIO; 10–5 mol l–1), 1H-[1,2,4]oxadiazole-[4,3-a]quinoxalin-1-one (ODQ; 10–5 mol l–1) and 8-bromo-guanosine 3'5'-cyclic monophosphate (8Br-cGMP; 10–5 mol l–1) on stroke volume (VS) and stroke work (WS) in isolated and perfused icefish hearts. Percentage changes were evaluated as means ± S.E.M. of four experiments for each group. Asterisks indicate values significantly different from the control value: *P<0.05; **P<0.025).