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Fig. 1. Schematic diagram of the running wheel enclosure. A, wheel axle (attached to the back side of the housing); F, fan; T, recirculation tube; C, mouse cage; D, access door; E, wheel entry tube; P, waste pan; G, wheel speed generator; S, space filler. Not shown: food hopper, drinking tube, air access ports, other space fillers in corners of wheel housing and around mouse cage. The internal volume (without cage, bedding, and food) is approximately 22.7 liters.