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Fig. 1. Myoglobin is expressed in oxidative skeletal myofibers. (A) Schematic of fiber-type diversity associated with mammalian skeletal muscle. Skeletal myofibers are characterized based on the myosin heavy chain (MHC) isoforms, oxidative capacity (i.e. mitochondrial content), contractility (slow-twitch vs fast-twitch) and myoglobin content. Myoglobin is expressed in Type I, 2A and 2X fibers (absent in 2B fibers). (B,C) Low-magnification (B) and high-magnification (C) transverse sections of adult mouse hindlimb skeletal muscle immunohistochemically stained for myoglobin expression. Note that myoglobin is expressed in a graded fashion in oxidative myofibers (Type I>2A>2X and absent in 2B fibers). 1, Type 1 fibers; 2, Type 2A fibers; 3, Type 2X fibers; 4, Type 2B fibers.