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Fig. 5. Time-dependent effects of zatebradine (1 mg ml-1) on heart rate (fH) and preload pressure (Pin) in the perfused heart. Zatebradine-perfused hearts (closed symbols, N=5) are shown together with control perfused hearts (open symbols, N=4) to account for the possible deterioration of the preparation over time. Values are means ± S.E.M.