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Fig. 3. Effect of zatebradine (ZAT) (dose equivalent to the Km for each individual fish; see Materials and Methods) on (A) dorsal aortic pressure (PDA), (B) peripheral resistance (Rsys), (C) heart rate (fH), (D) relative cardiac output () and (E) relative stroke volume (VS). Values are means ± S.E.M. (N=14). Asterisks indicate significant difference from the control value (P<0.05).