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Fig. 3. Effects of oxygen on recombinant NMDA receptor currents in Xenopus oocytes. Hypoxia activates or inhibits cloned NMDARs expressed in Xenopus oocytes depending on the NR2 subunit. (A) Hypoxia has no effect on currents from NR1/NR2A and NR1/NR2B receptors. (B) Hypoxia inhibits currents from NR1/NR2D and augments those from NR1/NR2C. (C) Example of the augmenting effects of hypoxia on currents recorded from an oocyte expressing NR1/NR2C receptors. (D) Example of the inhibition of currents from NR1/NR2D during hypoxia. Reprinted from Bickler et al. (2003), with permission.