Fig. 4. Changes in cortical capillary density during prolonged hypoxia and deadaptation. (A) Composite photomicrograph of GLUT-1-stained sections spanning part of the parietal cortex at normoxia, 21 days (21 d) of hypoxia, and normoxic recovery for 21 days. (B) Capillary density analysis of GLUT-1-stained sections showing a significant increase at 21 days of hypoxia (21 d H). Subsequent normoxic recovery (7 d R, 14 d R, or 21 d R) caused reestablishment of prehypoxic capillary density. Values are means ± S.D.; N=4 rats in each group. ^*P<0.05 compared with controls (C). Reprinted with permission from Pichiule and LaManna (2002).