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Fig. 4. Effects of cGMP (500 µmol l–1) on the transepithelial voltage Vt (A) and resistance Rt (B) in isolated perfused Malpighian tubules and on the basolateral membrane voltage Vbl (C) and input resistance Rpc (D) of principal cells of Malpighian tubules of A. aegypti. Values are means ± S.E.M.; N=20 (A–C), N=21 (D) tubules or cells; *P<0.05, paired Student's t-test.