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Fig. 4 Changes in body composition at 14 weeks after weight implantation in male and female mice relative to initial body composition. (A) Relative changes in fat mass. There was a significant gender effect on changes in fat mass (P=0.046). (B) Relative changes in lean body mass. SO, sham-operated mice (white bars); LO, mice containing implants corresponding to 2% of body mass (grey bars); HI, mice containing implants corresponding to 10% of body mass (black bars). Data (%) are expressed relative to values measured at weight implantation, and are means ± S.E.M., N (male/female): SO (7/5), LO (9/7), HI (7/7). {dagger}P=0.052 vs. SO (Dunett's-test).