Fig. 1. Changes in total body mass (M_TB; A), biological body mass (M_BB; B), and energy intake after implantation of weight load (C) into male and female mice. SO, sham-operated mice (open circles); LO, mice containing implants corresponding to 2% of body mass (closed circles); HI, mice containing implants corresponding to 10% of body mass (closed triangles). Data are expressed relative (%) to values measured 3 weeks (for energy intake) and 1 week (for body mass) prior to implantation of the weight load (time 0). Body mass at time 0 was measured immediately after weight implantation; body mass at other time points is the mean of three measurements taken during 1 week. Values are means ± S.E.M., N (male/female): SO (12/11), LO (12/12), HI (10/14), ^*P<0.05 vs. SO (Dunett's-test).