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Fig. 2. Phylogenetic tree showing the relationships between the ß and ß-like subunits of soluble guanylyl cyclases. The first atypical guanylyl cyclase subunit characterized, MsGC-ß3, clusters close to Gyc-88E, CP12881 from Anopheles and GCY-31 from C. elegans. A second grouping contains the remaining atypical subunits from Drosophila, Gyc-89Da, Gyc-89Db, P3998 from Anopheles, and GCY-33 from C. elegans. All the conventional soluble ß1 subunits, which form NO-sensitive {alpha}1/ß1 heterodimers, cluster together in a group that includes both vertebrate and invertebrate subunits. The remaining soluble guanylyl cyclases from C. elegans cluster together in a separate grouping and the mammalian ß2 subunits also appear to form a separate distinct cluster.