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Fig. 9. 5-HT induced rise in EOD repolarization time ({tau}-P2) versus rise in amplitude, expressed as a percentage of the day—night swing, illustrates how the serotonin-induced changes in repolarization time and amplitude are semi-independent. Note that most of the data fall above the 1:1 ratio (broken) line, indicating that both variables may change or repolarization time may change alone, but amplitude never changes without a change in repolarization time. Values shown are for males injected with 5-HT doses 0.75 nmol g-1 and higher.