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Fig. 2. Response of basolateral membrane potential (Vbl) to glibenclamide (Glib.). In a low [K+] bath (5 mmol l-1 K+) Vbl responded to glibenclamide by either (A) a small but significant hyperpolarization of 3.6±1.2 mV (P=0.01, n=8) or (B) a significant depolarization of 9±1.5 mV (P=0.008, n=4). Addition of 6 mmol l-1 Ba2+ reinforced the initial response of glibenclamide.