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Fig. 3. (A) The effects of various inhibitors on lactate efflux from trout white muscle sarcolemmal vesicles. All vesicles were loaded with 25 mmol l-1 lactate and 18.5 kBq 14C-lactate. Values are means ± 1 S.E.M. Control (N=5): efflux was measured in KCl/Mops buffer; STOP (N=10), efflux in ice-cold, 2.5 mmol l-1 HgCl2; 75 mmol l-1 Na (N=7): efflux in 75 mmol l-1 KCl, 75 mmol l-1 NaCl Mops buffer; 5 mmol l-1 CIN (N=6): efflux in KCl/Mops containing 5 mmol l-1 {alpha}-cyano-4-hydroxycinnamate; 5 mmol l-1 SITS (N=11): efflux in KCl/Mops containing 5 mmol l-1 4-acetoamido-4'-isothyiocyanstilbene-2,2'-disulphonic acid. *A significant difference (P<0.05) from the control value. (B) The influence of pH gradient on lactate efflux from trout white muscle sarcolemmal vesicles. Values are means ± 1 S.E.M. pHi<pHe, N=11; pHi>pHe, N=7, pHi=pHe=5.1, N=5; pHi=pHe=7.4, N=6. *A significant difference (P<0.05) from the pHi=pHe=7.4 value.