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Fig. 9. Cross talk between the endocardial endothelium (EE) and the myocardium in A. anguilla. Endoluminal ANG II activates AT1-like receptors in the EE that stimulate NO release, eliciting in the subjacent myocardium the negative inotropism through a cGMP-PKG mechanism. NO, nitric oxide; Gi/o, Gi/o proteins; MR, muscarinic receptor; PKG, cGMP-activated protein kinase; GC, guanylate cyclase; eNOS, endothelial nitric oxide synthase.