Fig. 9. An illustrative example of the mechanobiological paradigm's predictive value. Here, the magnitude of strain graphically dictates the differentiation of cartilage (shown in red) versus fibrous tissue (shown in blue) within the mechanically stimulated defects. The defect shown in A underwent 10% cortex diameter shear, whereas the defect shown in B underwent 25% shear. Thus, a threshold exists between these shear magnitudes that determines cartilage versus fibrous tissue outcomes.