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Fig. 1. (A) Summary diagram of the standard model of metabolic regulation; in this conceptualization, accelerating tissue ATP utilization leads to increasing concentrations of ADP and Pi, which serve as substrates for oxidative phosphorylation, to activate ATP production. (B) Summary of an alternative model of metabolic regulation in which ATP demand and ATP supply pathways are simultaneously activated during large-scale change in tissue work rates. See text for further details.