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Fig. 4. Hypothetical representation of cellular zinc uptake pathways in fish combining data from gill and intestine. See text for more details. Li, aquatic ligand; ZIP1, Zrt, Irt-like protein; EcaC, putative lanthanum-sensitive epithelial calcium channel; ZTL, zinc-regulated zinc transporter; AA, amino acid; AAT, amino acid transporter; ZNT1, zinc transporter 1. Briefly, zinc enters via either a putative calcium channel, a ZIP-`like' transporter, ZTL a zinc transporter similar to zinc transporter 1 (ZnT-1), or bound to an amino acid (i.e. histidine), via an amino acid transporter. Excess cytoplasmic zinc is bound to metallothionein (MT). Basolateral transfer is via a Znt-1.