Fig. 3. Change in preferred body temperature (T_b) over time of control, sham-operated and preoptic area (POA)-lesioned toads injected into the lymph sac at time zero with either (A) pyrogen-free saline or (B) lipopolysaccharide (LPS) at a dose of 200 µg kg^-1 body mass. A non POA-lesioned group injected with LPS is also plotted. Arrows indicate the time of injection. Values are means ± S.E.M. The asterisk indicates significant difference (P<0.05) from the control group at the same time points. Numbers in parentheses indicate the number of animals.