Fig. 1. CAATCH1 (TC 2.A.22.2.4 transporter superfamily classification),
Na+:neurotransmitter transporter family members (SNF; TC 2.A.22)
all possess a conserved tyrosine residue (filled circles). (A) Location of
Tyr147 in the third transmembrane domain of CAATCH1. The predicted
secondary structure is adapted from Feldman et al.
(2000). (B) Alignment of third
transmembrane domain residues of CAATCH1 with some representative members of
the SNF family showing a universally conserved tyrosine residue representing
Tyr147 in CAATCH1
(http://ca.expasy.org/cgi-bin/blast.pl?sequence=Q9U5A9
).