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Fig. 8. Phylogenetic tree for selected Na+/H+ exchangers (NHEs). Protein sequences are those aligned in Fig. 7, produced using TreeViewPPC and ClustalW software. The boxed names are the Drosophila NHEs, and the other abbreviations are as follows: Xenopus NHE, Xenopus laevis, CAA69925 (Busch, 1997); human NHE1, Homo sapiens, AAB59460 (Sardet et al., 1988); nNHE chr1, Homo sapiens, Hs1_5070 chromosome 1 working draft sequence; human NHE2, Homo sapiens, XP_010884 (NCBI Annotation Project; direct submission, 2001); human NHE4, Homo sapiens, P26434 (Orlowski et al., 1992); nNHE chr2, Homo sapiens, Hs2_5544 chromosome 2 working draft sequence; human NHE5, Homo sapiens, NP_004585 (Klanke et al., 1995); nNHE chr16, Homo sapiens, Hs16_10635 chromosome 16 working draft sequence; C. elegans NHE, Caenorhabditis elegans, P35449 (Marra et al., 1993); nNHE chr3, Homo sapiens, Hs3_19514 chromosome 3 working draft sequence; NHE Arabidopsis, Arabidopsis thaliana, AAF21755 (Quintero et al., 2000); DmNHE3, Drosophila melanogaster, AAF13702 (this work); nNHE chrX2, Homo sapiens, HsX_11991 chromosome X working draft sequence; human NHE6, Homo sapiens, AAC39643 (Numata et al., 1998); nNHE chr12, Homo sapiens, Hs12_9838 chromosome 12 working draft sequence; nNHE chrX, Homo sapiens, HsX_11725 chromosome X working draft sequence; S. cerevisiae NHE, Saccharomyces cerevisiae, Q04121 (Numata et al., 1998); S. pombe NHE, Schizosaccharomyces pombe, T37706 (L. Murphy, D. Harris, V. Wood, B. G. Barrell and M. A. Rajandream, unpublished); KIAA0939, Homo sapiens, CAB46030 (N. Corby, unpublished); DmNHE1, Drosophila melanogaster, AAD32689 (J. A. T. Dow, unpublished; and this work; nNHE chr13, Homo sapiens, Hs1_22216 chromosome 1 working draft sequence; nNHE chr20, Homo sapiens, Hs20_11518 chromosome 20 working draft sequence; nNHE chr10, Homo sapiens, Hs10_8739 chromosome 10 working draft sequence; nNHE chr12, Homo sapiens, Hs1_22246 chromosome 1 working draft sequence; nNHE chr22, Homo sapiens, Hs22_11677 chromosome 22 working draft sequence; human NHE3, Homo sapiens, P48764 (Brant et al., 1995); nNHE chr5, Homo sapiens, Hs5_7223 chromosome 5 working draft sequence; DmNHE2, Drosophila melanogaster, AAF53960 (this work); Aedes NHE3, Aedes aegypti, AF80554 (S. S. Gill, H. Wediak and L. S. Ross, unpublished); NHE crab, Carcinus maenas, AAC26968 (Towle et al., 1997). nNHE denotes a novel or undocumented gene in the human genome sequence.