Fig. 6. Structure predictions for human NHE1, DmNHE1, DmNHE2 and DmNHE3. Transmembrane probability plots for human NHE1, DmNHE1, DmNHE2, Aedes aegypti NHE3 and DmNHE3 proteins according to the von Heijne (von Heijne, 1992) algorithm. Predictions were made using MacVector 7.0. The blue background indicates the N-terminal domain; white, the compact transmembrane domain; yellow, the C-terminal cytoplasmic domain. Putative signal peptide cleavage sites are marked with red arrowheads. All three gene models for DmNHE2 are shown (see text) with the Aedes aegypti sequence for comparison.