
Fig. 3. Radial phylogenetic tree depicting the evolutionary relationship of Fundulus heteroclitus 14-3-3.a to the seven known mammalian and some Xenopus laevis 14-3-3 isoforms. 14-3-3 proteins from different vertebrates (labeled with species name) that are of the same isoform-type (either
, ß,
,
,
,
, or
) cluster together (gray background). Such clusters are labeled with the isoform-type of the corresponding 14-3-3 proteins in each cluster. F. heteroclitus 14-3-3.a (boxed in red) may be evolutionarily distinct from the 14-3-3 isoforms that are known from higher vertebrates or be a homolog of 14-3-3
or 14-3-3ß.